Boron plays a vital role in mineral metabolism, hormone regulation, and reducing inflammation. It can improve bone health and insulin sensitivity.

Reference Pizzorno, L. (2015). Nothing boring about boron. Integrative Medicine: A Clinician's Journal, 14(4), 35.

Dosing Typically 3-6 mg daily.

ContraindicationsPregnancy, lactation, kidney disease.

Metabolic Impact Boron's subtle, yet broad, impacts on enzymatic pathways and hormone modulation are often overlooked in standard medical training. Its effects are not dramatic like some pharmaceuticals, which lead to a misunderstanding regarding its clinical usefulness. Additionally, serum level testing is not standard, which leads many to disregard this valuable mineral. Boron also has anti-inflammatory effects, and can help to modulate the body's inflammatory response.

Copper and Zinc are essential trace minerals that support immune function, antioxidant defenses, and enzyme activity. Maintaining the right ratio is crucial for metabolic processes.

Reference Prasad, A. S. (2013). Discovery of human zinc deficiency: its impact on human health and disease. Journal of trace elements in medicine and biology, 27(2), 101-107.

Dosing Zinc: 15-30 mg daily; Copper: 1-2 mg daily (maintain a balanced ratio).

Contraindications Wilson's disease (copper overload).

Metabolic Impact The intricate balance between copper and zinc is frequently oversimplified. Many don't grasp the concept that seemingly adequate 'normal' ranges on standard blood tests might not reflect optimal cellular function. Also, the food industry, and it's large focus on zinc alone, has greatly disturbed the careful copper to zinc balance that is required for proper human health. Zinc is vital for proper insulin signaling, and both copper and zinc are required for proper immune function.

Vitamin D3 regulates calcium and insulin sensitivity, while K2 directs calcium to bones and teeth, preventing arterial calcification. Together, they support metabolic function and cardiovascular health.

Reference Schwalfenberg, G. K. (2011). Vitamin D importance: beyond calcium and bone. Journal of family practice, 60(10), 636-641.

Dosing Vitamin D3: 2000-5000 IU daily; Vitamin K2 (MK-7): 100-200 mcg daily.

Contraindications Hypercalcemia, kidney stones (for high-dose D3).

Metabolic Impact The synergistic action of D3 and K2 is often underappreciated. Vitamin D's role in calcium absorption is well-known, but K2's crucial function in directing calcium to the bones and away from arteries is often missed. Traditional medical training has historically focused on D3 alone, causing to miss the massive cardioprotective effects from the combination of the two vitamins. Vitamin D is also a powerful modulator of the immune system, and can often improve autoimmune conditions.

This blend of vitamins and minerals is designed to enhance sleep quality, which is crucial for metabolic regulation, hormone balance, and weight management.

Reference St-Onge, M. P., Mikic, A., & Pietrolungo, C. E. (2016). Effects of diet quality and sleep duration on biomarkers of adiposity and metabolic syndrome. Physiology & behavior, 162, 309-316.

Dosing Follow product label directions.

Contraindications Individual ingredient sensitivities.

Metabolic Impact Many over simplify sleep support, and do not understand the large quantity of nutrient depletions that modern life causes. They focus on singular medications, instead of the multiple combined, and synergistic vitamin and mineral needs that allow people to properly produce neurotransmitters that allow for adequate sleep. Proper sleep is required for proper insulin sensitivity, and weight management.

Krill oil's omega-3 fatty acids, particularly EPA and DHA, reduce inflammation, improve lipid profiles, and support cardiovascular health. The phospholipid bound omega 3s have a higher bioavailability than standard fish oil.

Reference Cicero, A. F. G., Fogacci, F., & Banach, M. (2019). Red krill oil improves lipid profile, glycaemic control and systemic inflammation in patients with mild hyperlipidaemia: a 3-month pilot study. Nutrition research, 64, 77-88.

Dosing 4-6 grams daily.

Contraindications Seafood allergies, bleeding disorders.

Metabolic Impact The phospholipid-bound omega-3s in krill oil offer enhanced bioavailability compared to traditional fish oil, yet this distinction is often overlooked. Therefore proper dosing of krill oil, does not directly translate from fish oil dosing. This means that krill oil may be far more effective at lower doses, than a same dose of fish oil. Also, physicians are often very reluctant to recommend higher dosing of omega 3's in general, due to blood thinning concerns, which leads to inefficacious dosing of these supplements. Omega 3's are extremely effective at reducing systemic inflammation.

Copaiba oil contains beta-caryophyllene, which interacts with the endocannabinoid system to reduce inflammation and support overall well-being.

Reference Rodrigues, K. C., Resende, F. A., Silva, J. M., Cunha, L. C., & Costa, P. M. (2015). β-Caryophyllene, a natural sesquiterpene, modulates cytokines production and oxidative stress in murine macrophages. Evidence-Based Complementary and Alternative Medicine.

Dosing Follow product label directions.

Contraindications Pregnancy.

Metabolic Impact The endocannabinoid system's role in modulating inflammation and metabolic function is often underappreciated. Copaiba oil's interaction with this system can provide significant anti-inflammatory benefits, which can positively impact metabolic health.

Castor oil packs can stimulate lymphatic circulation and detoxification processes, supporting liver health and reducing inflammation.

Reference Grady, H. (2000). Janice kellogg's castor oil therapy. Baar Products.

Dosing Topical application as castor oil packs.

Contraindications Pregnancy, intestinal obstruction.

Metabolic Impact The importance of lymphatic circulation in detoxification and immune function is often overlooked. Castor oil packs can support these processes, which can indirectly improve metabolic health.